Our Publications
Kraft K*, Murphy SE*, Jones MG*, Shi Q, Bhargava-Shah A, Luong C, Hung KL, He BJ, Li R, Park SK, Montgomery MT, Weiser NE, Wang Y, Luebeck J, Bafna V, Boeke JD, Mischel PS, Boettiger AN, Chang HY. Enhancer activation from transposable elements in extrachromosomal DNA. Nature Cell Biology (2025).
Weiser NE, Watkins TBK, Chang HY, Mischel PS. A guide to extrachromosomal DNA: cancer’s dynamic circular genome. Cancer Discovery (2025).
Kirshner J*, Picard C*, Weiser NE, Mehta N, Feng S, Murphy V, Vakhnovestsky A, Alessi A, Xiao C, Inoki K, El Mouridi S, Jacobsen SE, Kim JK. Regulation of MORC-1 is key to the C. elegans CSR-1 germline gene licensing mechanism in C. elegans. Science Advances (2025).
Huang YH*, Belk JA*, Zhang R, Weiser NE, Chiang Z, Jones MG, Mischel PS, Buenrostro JD, Chang HY. A unified molecular approach for spatial epigenome, transcriptome, and cell lineages, PNAS (2025).
Tang J*, Weiser NE*, Wang G*, Chowdhry S, Curtis EJ, Zhao Y, Wong ITL, Marinov GK, Li R, Hanoian P, Tse E, Mojica SG, Hansen R, Plum J, Steffy A, Milutinovic S, Meyer ST, Luebeck J, Wang Y, Zhang S, Altemose N, Curtis C, Greenleaf WJ, Bafna V, Benkovic SJ, Pinkerton AB, Kasibhatla, Hassig CA#, Mischel PS#, Chang HY#. Enhancing transcription-replication conflict targets ecDNA-positive cancers. Nature (2024)
Bailey C*, Pich O*, Thol K, Watkins TBK, Luebeck J, Rowan A, Stavrou G, Weiser NE, Dameracharla B, Bentham R, Lu WT, Kittle J, Yang SYC, Howitt BW, Sharma N, Litovchenko M, Salgado R, Hung KL, Cornish AJ, Moore DA, Houlston TS, Bafna V, Chang HY, Nik-Zainal S, Kanu N, McGranahan N, Genomics England Consortium, Flanagan AM, Mischel PS, Jamal-Hanjani M, Swanton C. Origins and impact of extrachromosomal DNA. Nature (2024).
Weiser NE, Hung KL, Chang HY. Oncogene convergence in extrachromosomal DNA hubs. Cancer Discovery (2022).
Hung KL, Luebeck J, Dehkordi SR, Colon CI, Li R, Wong IT, Coruh C, Dharanipragada P, Lomeli SH, Weiser NE, Moriceau G, Zhang X, Bailey C, Houlahan KE, Yang W, Chamorro R, Swanton C, Curtis C, Jamal-Hanjani M, Henssen AG, Law JA, Greenleaf WJ, Lo RS, Mischel PS, Bafna V, Chang HY. Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nat Genetics (2022).
Hung KL*, Yost KE*, Xie L*, Shi Q, Helmsauer K, Luebeck J, Schopflin R, Lang JT, Weiser NE, Chen C, Valieva M, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Ganja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen A, Mischel PS, Liu Z, Chang HY. ecDNA hubs drive cooperative intermolecular oncogene expression. Nature (2021).
Weiser NE and Kim JK. Multigenerational regulation of germline gene expression and the chromatin landscape by C. elegans small RNAs. Annual Review of Genetics (2019).
Weiser NE, Yang DX, Feng S, Kalinava N, Brown KC, Khanikar J, Freeberg MA, Snyder MJ, Csankovszki G, Chan RC, Montgomery TA, Gu SG, Jacobsen SE, Kim JK. MORC-1 integrates nuclear RNAi and transgenerational chromatin architecture to promote germline immortality. Developmental Cell 2017).